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Education

Swansea Uni to deliver advanced therapies

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A significant opportunity: University a centre for cell and gene therapies

SWANSEA U​NIVERSITY’S​ Medical School, through its partnership with Abertawe Bro Morgannwg University Health Board, is to be one of the centres to deliver advanced medical therapies to Wales, which is part of a major investment announced by Welsh Blood Services.

A recently formed health consortium, jointly led by the Welsh Blood Service (on behalf of NHS Wales) and the National Institute for Health Research Birmingham Biomedical Research Centre, has been awarded £7.3M of UK Government funding to ensure more patients benefit from a new generation of breakthrough therapies.

£1.5M will come directly to NHS Wales and £550K to Trakcel, a Welsh software company developing scheduling/tracking software for advanced therapies which is based upon technology developed at Swansea University.

The funding will support the Welsh Government’s commitment to developing an Advanced Therapies Strategy which will enable these therapies to be brought to Welsh patients and Advanced Therapy Medicinal Product (ATMP) companies to reach the clinical market, whilst building expertise, capability and capacity across NHS Wales to benefit patient outcomes.

Speaking of the award, Frank Atherton, Chief Medical Officer for Wales, said: “We welcome the announcement of the successful partnership between Birmingham, Nottingham and Wales NHS centres in bidding for Innovate UK monies. The project is aligned with our ambition to support the development, availability and adoption of new innovative therapies for patients in Wales. Cell- and gene-based advanced therapies offer exciting opportunities, not only for the way we treat people with previously incurable conditions, but also how we work together with industry and NHS Wales in bringing these treatments from bench to bedside.”

The NHS Wales role in the MW-ATTC consortium was led by the Welsh Blood Service, with support from Abertawe Bro Morgannwg and Cardiff & Vale University Health Boards along with the Life Sciences Hub Wales Special Interest Group on Cell and Gene Therapy, which brings together expertise from the Welsh NHS, Universities and industry in the Life Science sector.

As part of the contract award, one of the first advanced therapy treatment sites in Wales will be established within Abertawe Bro Morgannwg at the Joint Clinical Research Facility (JCRF) at Swansea University’s Medical School. The focus of the centre will be to develop the infrastructure, processes and skilled workforce required to enable patients to be cared for, from diagnosis through to post-treatment follow up.

Cath O’Brien, Director of the Welsh Blood Service and MW-ATTC Co-Director, said: “A significant opportunity exists to position Wales as a leader in clinical trial and routine delivery of cell and gene therapies to maximise Welsh patient benefit and opportunities for the national economy. The Welsh Government is committed to exploring these revolutionary developments in healthcare and we are excited to have worked alongside our consortium partners to secure funding through what was a highly competitive tendering process.”

One of the first products that will pass through the Welsh centres is that being developed by one of the consortium partners, Rexgenero and is intended to prevent the need for diabetes-related lower limb amputations for some no option patients. The incidence of diabetes is continuing to increase in Wales and already accounts for ~10% of the NHS Wales budget (£500M) with 200, 000 sufferers today rising to an estimated 500,000 by 2025. Currently around 2000 patients in Wales have non-healing lower limb ulcers that result in approximately 330 amputations per year.

The Midlands & Wales Advanced Therapy Treatment Centre (MW-ATTC) will identify barriers, challenges and solutions to facilitate future deployment and adoption of these transformative therapies within the UK healthcare system.

Advanced treatments, such as cell and gene therapies, show great promise for patients with chronic and terminal conditions that currently cannot be cured. Unlike conventional medicines, these new approaches often aim to selectively remove, repair, replace, regenerate and re-engineer a patient’s own genes, cells and tissues to restore normal function. The project will include potential treatments for arthritis, liver disease, several types of cancer, and diabetic ulcers.

Education

School to share digital experience under lockdown

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Greenhill School in Tenby is set to share their digital journey with other
educators in Wales next week in a national webinar.

Leading their part of the webinar will be Jonathan Evans, Greenhill’s DCF
(Digital Competence Framework) lead, who will be accompanied by Vicki
Price (the school’s Head of Computing) to talk about how staff, pupils and
parents have embraced digital engagement and training since the
lockdown started.

They were approached by Ryan Evans, Google Trainer with Aspire2Be, to
be part of the webinar with him and other Google experts.

Vicki said it was a fantastic opportunity to showcase what the school has
been doing.

“Jonathan has held a twice-weekly geek meet online with staff which has
been very successful,” she said.

“He has created a resources website for staff, pupils and parents to
support them. On top of this, staff meet daily on Microsoft Teams to
discuss the day ahead giving them valuable time to connect with each
other.

Vicki added: “The school has fully embraced many features of the Hwb
Platform, some more successfully than others, and we hope that by taking
part in this webinar we can show others the journey our staff, pupils and
parents have taken in these challenging times.”

The webinar will be held via Hwb on Tuesday, 12 th May at 12:30pm as part
of a demonstration of Creative Writing Using G Suite.
You can register here to view the webinar:

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Education

Ancient Connections – Pembrokeshire and Wexford stories to be retold by school children through animation

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Ancient Connections – a three-year arts, heritage and tourism project linking North
Pembrokeshire and North Wexford is delighted to celebrate the start of a cross-border
schools project which began in March 2020 and is expected to continue until Spring 2021.
The project will bring three schools together in the ambitious creation of a short animation
film telling the stories of connection between these two regions. The participating schools
are Ysgol Penrhyn Dewi in St Davids, Pembrokeshire, Scoil Naomh Maodhog Ferns and St
Edan’s School, both in Ferns, County Wexford. In March, the project kicked off with a group
of 19 pupils aged 12-13 plus staff traveling from St Davids to Ferns to meet and get to know
their peers in the Ferns schools. The group have been learning about their own heritage
stories, as well as the stories that link these two regions through working with Fishguard
based storyteller Deb Winter. In Ferns, the group performed these stories and in turn
listened to their Irish counterparts, who had been coached by storyteller Lorraine O’Dwyer.
Cilla Bramley, Head of Expressive Arts at Ysgol Penrhyn Dewi said:

I just wanted to send a HUGE thank you from all at Ysgol Penrhyn Dewi for the amazing visit
we had to Ireland. The pupils and I were so 'blown away' by the incredibly warm Irish
welcome and every aspect of our visit was perfect! The arrival at Scoil Maodhog was moving
and our pupils are now texting, snap chatting/what's apping etc. and looking forward to the
return visit. All the excursions were fabulous and informative and when I asked pupils what
their favourite aspect of the trip was, not one of them could decide as there were just too
many things to pick from.

Due to the COVID-19 outbreak, the project will now continue through online and digital
means, until September 2020 when they will begin work with Cardiff based animation
studio Winding Snake to creatively retell these stories through different animation
techniques, culminating in a short film that will be screened in venues and online in 2021.
Amy Morris, Director of Winding Snake says:

"The team at Winding Snake are thrilled to be working with the schools involved as part
of this exciting and historic project.  We can't wait to get stuck in and start making! The
young people taking part will work with us to create animation, learn musical composition,
make foley and sound effects, participate in script writing and storytelling sessions, and will
work with professional actors to learn acting and performance skills. With lots and lots of
arts and craft thrown into the mix too, it's going to be a wonderful project." 
A short documentary film about the project will also be created by filmmaker Terence White
based in Wexford.

Community and academic research led by Angharad Wynne and Abarta Heritage has
unearthed some fascinating stories that link these two ancient Celtic lands. From the deep
friendship between St David and St Aidan, founder of Ferns Monastery, to strategic
marriages between powerful Irish Kings and the daughters of Norman knights in the
Mediaeval period, to human entanglement with mysterious and mythical sea creatures as
well as inclement weather causing shipwrecks on unforgiving coasts.

The Animating schools project forms one aspect of the wider Ancient Connections project,
with the aim of motivating both communities to rediscover their shared heritage; to be
mentors for one another; sharing knowledge, experience and skills to create a stronger
sense of identity and place that will continue to flourish in years to come. The stories that
emerge from the project will also be employed to create ways to attract visitors to North
Pembrokeshire and Wexford outside of school and summer holidays.

Ancient Connections is led by Pembrokeshire County Council, together with partners
Wexford County Council, Pembrokeshire Coast National Park Authority and Visit Wexford
funded by the European Regional Development Fund through the Ireland Wales co-
operation programme

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Education

Marine energy presents an ocean of opportunity

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Before lockdown, Pembrokeshire College, in collaboration with marine sector employers, recently hosted a STEM Careers in Marine Energy event for local students.

The event, organised in partnership with the Port of Milford Haven, the Coastal Communities Adapting Together project, Pembrokeshire Coastal Forum, Mainstay Marine, Bombora, ORE Catapult, Centre for Sustainable Aquatic Research (Swansea University) and the Bucanier Project, was designed to raise the profile of the marine energy sector.

With exciting and imminent developments in marine energy in south Pembrokeshire, the purpose of the event was to introduce possible new careers in marine energy (both locally and globally) to 70 STEM students, sowing the seeds of local development and regeneration.

A-level pupils from Ysgol Harri Tudur, along with A-level and engineering students from Pembrokeshire College, were invited to attend the event, which saw the Bridge Innovation Centre in Pembroke Dock transformed into a series of interactive workshop spaces.

David Jones the CEO of Pembrokeshire Coastal Forum, and Andy Edwards, Port of Milford Haven’s Vice-Chair, opened the event by setting the scene around present and future careers in marine energy. Interactive workshops were led by local marine energy developers; Bombora Wave Power, Mainstay Marine Solutions, Pembrokeshire Coastal Forum, and Swansea University.

The students joined in the innovation focused workshops which included building their own floating wind turbine platform, against the clock.

The new Guide to Careers in Marine Energy was also launched at the event. This has been developed collaboratively between the marine energy industry and the supply chain to showcase the industry and possible careers within it. English and Welsh versions will be made available to learning institutions locally and online as a learning resource, in time for the next academic year.

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