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Reprogrammed virus offers hope as cancer treatment

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A CANCER treatment that can completely destroy cancer cells without affecting healthy cells could soon be a possibility, thanks to research led by Cardiff University.

The team of researchers has successfully ‘trained’ a respiratory virus to recognise ovarian cancer and completely destroy it without infecting other cells. The reprogrammed virus could also be used to treat other cancers such as breast, pancreatic, lung and oral.

Dr Alan Parker from Cardiff University’s School of Medicine said: “Reprogrammed viruses are already being used in gene therapy procedures to treat a range of diseases, demonstrating they can be trained from being life-threatening into potentially lifesaving agents.

“In cancer treatment, up until now, reprogrammed viruses have not been able to selectively recognise only the cancer cells and would also infect healthy cells, resulting in unwanted side effects.

“We’ve taken a common, well-studied virus and completely redesigned it so that it can no longer attach to non-cancerous cells but instead seeks out a specific marker protein called αvβ6 integrin, which is unique to certain cancer cells, allowing it to invade them.

“In this case we introduced the reprogrammed virus to ovarian cancer which it successfully identified and destroyed.

“This is an exciting advance, offering real potential for patients with a variety of cancers.”

Once the virus enters the cancer cell it uses the cell’s machinery to replicate, producing many thousands of copies of itself, prior to bursting the cell and thereby destroying it in the process. The newly released viral copies can then bind and infect neighbouring cancer cells and repeat the same cycle, eventually removing the tumour mass altogether.

The virus also activates the body’s natural immune system, helping it to recognise and destroy the malignant cells.

The reprogrammed virus is from a group of respiratory viruses called adenoviruses. The advantage of using these viruses is that they are relatively easy to manipulate and have already been safely used in cancer treatment.

The technique used to reprogramme the virus to identify the protein common to ovarian, breast, pancreatic, lung and oral cancers could also be used to manipulate it so that it would recognise proteins common to other groups of cancers.

Additional refinement to the viral DNA could also allow the virus to produce anticancer drugs, such as antibodies, during the process of infecting cancer cells. This effectively turns the cancer into a factory producing drugs that will cause its own destruction.

The research was carried out in a laboratory, using mice with ovarian cancer, and has not yet reached clinical trials. The next step is to test the technique with other cancers, with a view to starting clinical trials in five years’ time.

Dr Catherine Pickworth from Cancer Research UK said: “It’s encouraging to see that this virus, which has been modified to recognise markers on cancer cells, has the ability to infect and kill ovarian cancer cells in the lab. Viruses are nature’s nanotechnology and harnessing their ability to hijack cells is an area of growing interest in cancer research.

“The next step will be more research to see if this could be a safe and effective strategy to use in people.”

The team includes researchers from Cardiff University; the Mayo Clinic in Rochester, USA; Glasgow University; the South West Wales Cancer Institute; and Velindre Cancer Centre.

The research was funded by Cancer Research UK, Tenovus Cancer Care and Cancer Research Wales.

The paper ‘Ad5NULL-A20 – a tropism-modified, αvβ6 integrin-selective oncolytic adenovirus for epithelial ovarian cancer therapies’ is published in Clinical Cancer Research.

 

Business

Welsh construction sector shows cautious optimism for 2026

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THE CONSTRUCTION sector in Wales is entering 2026 with cautious optimism, supported by continued public sector investment and a pipeline of major infrastructure and energy projects, according to a new report.

Analysis by Rider Levett Bucknall suggests that long-term commitments to energy transition, digital infrastructure and transport upgrades are helping to stabilise the market, despite ongoing global uncertainty.

Major projects highlighted in the report include the proposed Wylfa small modular reactor, the green industrial transition at Port Talbot, and the development of AI Growth Zones. These schemes are expected to create significant opportunities for contractors across Wales, particularly in infrastructure and energy resilience.

However, the report warns that short-term challenges remain. Global pressures, including instability in the Middle East, continue to create uncertainty, while longstanding domestic issues such as planning delays are still affecting progress.

Daniel Walker, an associate at the consultancy based in Cardiff, said that while activity levels remain steady, structural barriers are slowing delivery.

He said: “Across Wales, on-site construction activity remains steady, with visible progress across major centres including Cardiff, Swansea and several valley towns. However, structural challenges remain. Planning delays, particularly those linked to sustainable drainage system approvals, continue to slow early-stage progress on both private and public sector schemes.

“Despite this, and wider geopolitical uncertainty, the market has seen a slight increase in project starts over the past quarter.”

Public sector spending continues to underpin much of the activity. The report notes that devolved fiscal powers have unlocked an additional £505 million for infrastructure and local development, supporting projects in education, healthcare and transport.

Wales is also emerging as a growing hub for digital and energy infrastructure. Investment in data centres is ongoing, while preparatory work linked to Wylfa and the decarbonisation of steel production at Port Talbot is expected to drive demand for construction in the coming years.

Infrastructure remains one of the strongest-performing sectors, supported by transport upgrades and early work associated with the proposed Crossrail Cymru programme. Industrial and energy-related construction is also expanding as Wales accelerates its shift towards low-carbon industries.

In contrast, the high-end residential market has softened, although affordable housing and build-to-rent developments continue to perform more strongly.

The consultancy is currently involved in the Cowbridge Road East scheme in Cardiff, a project aimed at delivering affordable and sustainable housing. It said work is ongoing to ensure the scheme remains viable while helping meet demand for new homes.

The report concludes that, despite ongoing challenges, the combination of public investment, energy transition projects and digital growth places the Welsh construction sector on a broadly positive footing for 2026 and beyond.

Tender price inflation is forecast to remain stable, with a projected rate of 3.4% in Wales for 2026, slightly below the UK average of 3.45%.

 

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Cardiff Airport beats major hubs on delays — but questions remain over future

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CARDIFF AIRPORT has outperformed some of the UK’s busiest hubs for flight punctuality over the Easter period, according to new analysis — but longstanding concerns over its size, routes and public funding continue to cast a shadow over its future.

The study, based on Civil Aviation Authority data from April periods between 2022 and 2025, found that Cardiff Airport recorded a delay rate of 23.8% for departing flights. This placed it ahead of several major UK airports, including Heathrow Airport (26.4%), Gatwick Airport (26.0%), Edinburgh Airport (27.2%) and Newcastle International Airport (25.8%).

The figures, compiled by travel analysts Locals Insider, examined more than 650,000 flights across 24 UK airports, offering a snapshot of performance during one of the busiest travel windows of the year.

Smaller airport, smoother operations

Supporters say the findings highlight Cardiff’s reliability at a time when many passengers face disruption at larger, congested hubs.

A spokesperson for Locals Insider said the airport’s performance “paints a reassuring picture for Welsh travellers”, particularly as passenger numbers are expected to rise over Easter and new routes are introduced.

However, the data also reflects the scale difference between Cardiff and the UK’s largest airports. Over the four-year period analysed, Cardiff handled just 1,918 April flights — compared with nearly 148,000 at Heathrow alone.

This disparity means smaller airports can often maintain better punctuality simply due to lower traffic volumes and reduced pressure on infrastructure.

Wider challenges remain

Despite the positive figures, Cardiff Airport continues to face scrutiny over its long-term viability and performance.

The airport has been owned by the Welsh Government since 2013, and has received significant public investment in an effort to boost connectivity and economic growth.

Critics argue that passenger numbers remain relatively low and that the airport struggles to compete with nearby Bristol Airport, which offers a far wider choice of destinations and attracts millions more travellers each year.

There have also been ongoing questions about whether public funding represents value for money, particularly at a time of pressure on public services.

Growth and opportunity

Supporters of the airport point to signs of recovery and growth, particularly following the pandemic, with increased passenger demand and efforts to expand routes.

They argue that Cardiff plays a vital strategic role for Wales, providing international connectivity, supporting tourism, and contributing to the regional economy.

While the latest punctuality data offers a positive headline, the broader challenge remains whether Cardiff Airport can translate operational reliability into sustained growth and greater passenger numbers.

As the busy Easter travel period approaches, the airport may be performing well on timekeeping — but the debate over its future is far from settled.

 

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Scientists capture first-ever cosmic dynamo in action near Earth

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SCIENTISTS have observed a natural “cosmic dynamo” operating in near-Earth space for the first time, in a breakthrough that could transform our understanding of how magnetic fields are created across the Universe.

The discovery, led by the Space Research Institute of the Austrian Academy of Sciences and involving physicists from Aberystwyth University, provides the clearest evidence yet of one of the cosmos’s most fundamental processes.

Owen Roberts

Cosmic dynamos work by converting the motion of electrically charged gas – known as plasma – into magnetic fields. The same process is believed to power the magnetic environments of planets, stars and galaxies, but has never before been directly observed in space.

The new study, published in Nature Communications, identified clear signs of a turbulent small-scale dynamo inside Earth’s magnetosheath – the chaotic region where the solar wind collides with the planet’s magnetic field.

This boundary region, constantly compressed and reshaped by solar forces, offers a rare natural laboratory where scientists can study plasma behaviour in conditions impossible to recreate on Earth.

Dr Owen Roberts, of Aberystwyth University’s Department of Physics, said: “This is an extraordinary result. For the first time, we can see a natural plasma dynamo in action right on our cosmic doorstep.

“The measurements we take will help bridge the gap between laboratory experiments, computer simulations, and the real behaviour of space plasmas. Understanding how dynamo action works is essential for explaining the evolution of magnetic fields in planets, stars and galaxies.”

The breakthrough was made possible using NASA’s Magnetospheric Multiscale (MMS) mission – a fleet of four spacecraft flying in a precise pyramid formation. This configuration allowed scientists to capture simultaneous, three-dimensional measurements of plasma flows and magnetic fields.

Researchers observed magnetic fields being stretched, twisted and folded by turbulent plasma motions. They also identified regions where magnetic strength intensified – a key prediction of dynamo theory – alongside instabilities that allow the process to operate even without particle collisions.

These observations closely match decades of theoretical predictions and computer simulations, but have never previously been confirmed so clearly in space.

Dr Roberts added: “The four NASA spacecraft give us a 3D view of the turbulence, allowing us to observe magnetic fields stretching, twisting and growing exactly as theory predicts.

“Being able to witness these mechanisms in action transforms what was once purely theoretical into something we can measure and test. It’s a breakthrough that will reshape how we study magnetic fields throughout the cosmos.”

The findings bring scientists a significant step closer to understanding how magnetic fields are generated and sustained throughout the Universe – a process that plays a crucial role in shaping cosmic structure and behaviour.

 

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