News
Pembroke cancer sufferer given major lifeline by international drug company on compassionate grounds
Pembroke cancer sufferer Josh Carter-Hewins has been given a major lifeline following international drug company – Roche Pharmaceutical’s – decision, to grant him the Glofitamab drug on compassionate grounds.
Josh, who suffers from the rare and exceptionally aggressive Burkitt’s Lymphoma, was told by his consultants that he wasn’t eligible for further treatment.
But this week, Roche agreed to grant the Glofitamab drug to the 27-year-old on compassionate grounds.
“It’s absolutely fantastic that we have been heard,” Josh’s wife, Beth, told The Pembrokeshire Herald.
“What Roche has decided to do is exceptionally rare and has come as a huge shock to us all.”
The couple will now be travelling to London where Josh will commence his treatment which is expected to last between five and 12 months.
“Obviously there’s no guarantee that this drug will work, but this is our best hope,” said Beth.
Josh first began feeling unwell in 2021 when he was diagnosed with ulcerative colitis, which is a chronic inflammatory bowel disease. He later developed chronic liver disease and in 2023, underwent a liver transplant.
He made a good recovery, however earlier this year, he once again began feeling unwell.
“His symptoms were very similar to that of his ulcerative colitis with stomach pain, bloating and a general fatigue so initially, this is what we believed it was,” explained Beth.
But further analyses showed that Josh, who is employed as a CAD technician and account manager for the traffic light company, CORE highways, was suffering from the extremely rare post transplant lymphoma – Burkitt Lymphoma. Three weeks ago he was given a scan that showed his intensive chemotherapy had failed and his cancer was showing up in more places than before. He was also told that the only option available to treat the cancer is CAR-T cell therapy.
“But unfortunately Josh wasn’t eligible because his lymphoma is driven by being immunosuppressed,” said Beth.
“He wasn’t going to accept this, so he did his own extensive research and found the drug – Glofitamab – which has been used to treat a very small number of Burkitt’s Lymphoma cases across Canada, Copenhagen, Sweden and the USA. And all those cases have gone into remission.”
Sold under the brand name Columvi, this bispecific monoclonal antibody is used for the treatment of large B-cell lymphoma. However, because it isn’t licensed for use on Burkitt’s Lymphoma, the drug can only be administered through private hospitals.
“Josh and his consultants have made a huge effort researching, contacting other Burkitt’s Lymphoma survivors all over the world, holding discussions with doctors across the globe, meeting private consultants, holding meetings at the Senedd and more. We’ve also had extensive media coverage and every like, share, message and donation has made such a huge difference. We’ve been totally blown away by the way the community has come together to help us through this very difficult time.”
Meanwhile Josh and Beth are preparing themselves for the next chapter in their fight to combat Burkett’s Lymphoma.
“The gift from Roch doesn’t include the second drug, Polituzmab Vedotin, nor any other treatment which Josh may need, so we may still need to access private treatment along our journey. So all the donations we’ve received will be used to support his treatment and other potential options, if they become available.
“What Roche and NHS England are doing is fantastic, and they’re doing all they can to give Josh a chance.
“But we still want people to spread the word of Josh’s story, and help bring some light to people like him who are suffering from Burkitt’s Lymphoma.”
Crime
Detective Chief Inspector describes child’s death as ‘heartbreaking’
POLICE have described the death of seven-year-old Louis Linse at the hands of his mother as a “heartbreaking incident” that has deeply impacted officers and the local community.
Papaipit Linse, 43, from Haverfordwest, pleaded guilty to manslaughter by diminished responsibility at Swansea Crown Court earlier this week. Louis was found unresponsive in his bed on January 10 after Linse called emergency services to report his death.
Detective Chief Inspector Gary Williams, who led the investigation, reflected on the tragic events and the challenges faced by his team.
“This was a truly heartbreaking incident, involving the death of a young child at the hands of his mother,” DCI Williams said. “Officers who attended the scene were met with an incredibly difficult and emotive situation, yet they acted with professionalism and care, ensuring that a thorough investigation was conducted.”
The case has not only shocked the local community in Haverfordwest but has also brought to light the deep personal struggles and trauma faced by Linse in the years leading up to the tragedy.
A troubled family history
Linse, originally from Chiang Mai, Thailand, is the estranged wife of 51-year-old Edward Linse, a former businessman now detained in a psychiatric facility. Their marriage was marked by years of domestic violence, financial hardship, and failed business ventures.
In 2017, Edward assaulted his wife at their £1.2m Cheshire home during an argument about visa issues. The attack, carried out with a children’s book as a weapon, highlighted the volatile nature of their relationship. His lawyer, Peter Malone, told the court that Edward struggled to control his emotions, which he traced back to difficulties experienced during his boarding school years.
The violence escalated over the years, with Edward eventually convicted of a brutal assault on his own parents. Following his incarceration in a psychiatric facility, Linse was left to care for their two children alone.
The breakdown of their marriage was compounded by financial woes. After the failure of a café venture in Chiang Mai, the couple relocated to the UK. In 2022, their landscaping business, Alderley Landscapes, ceased trading, leaving Linse to move to Haverfordwest with her children in search of a fresh start.
Life in Haverfordwest
Neighbours in Upper Market Street described Linse as a quiet, reserved figure who homeschooled her two children. Despite her struggles, those close to the family said Louis appeared well-cared-for, with one neighbour, Dr Sean Phelan, expressing disbelief at the tragedy.
“I never thought something like this could happen,” Dr Phelan said. “The children were polite and seemed happy. It’s shocking to think of what must have been going on behind closed doors.”
Forensic teams have been working at the scene since the incident, piecing together the circumstances surrounding Louis’ death. Floral tributes have been placed outside the property as the community mourns the young boy’s loss.
Police dedication
DCI Williams praised the dedication of the officers involved in the investigation, acknowledging the emotional toll such cases can have on emergency responders.
“Our team has worked tirelessly since January to uncover the circumstances of Louis’ death and to ensure justice was brought for him,” he said. “While no result in court can undo this loss, we hope it offers some measure of closure to those who knew and loved Louis. Our thoughts remain with them during this devastating time.”
The case also serves as a reminder of the importance of early intervention and support for families facing domestic violence and mental health issues. Police urged anyone in similar situations to seek help from local services.
Awaiting sentencing
Linse has been remanded in custody and will be sentenced on December 13. The court is expected to consider the impact of her mental health struggles and the years of abuse she endured when determining her sentence.
As the investigation concludes, the police and community alike continue to grapple with the profound loss of a young life under such tragic circumstances.
Papaipit Linse: Admits killing her son, but denies murder
Business
Deposit Return Scheme diversion ‘illogical’ says Pembrokeshire brewery
TENBY HARBOUR BREWERY and local Senedd Member Samuel Kurtz have urged the Welsh Government to reconsider its decision to withdraw from a UK-wide Deposit Return Scheme (DRS) due to its insistence on including glass.
Earlier this week, Climate Change Secretary Huw Irranca-Davies announced that the Welsh Government would no longer participate in the development of a UK-wide DRS, citing issues arising from the UK Internal Market Act 2020. This decision is believed to be influenced by the Welsh Government’s plan to include glass in its scheme—a factor that contributed to the collapse of Scotland’s DRS in 2023.
The move has been met with frustration and anger from numerous organisations, who argue that this divergence will increase costs for Welsh producers and consumers.
Commenting on the matter, Samuel Kurtz said: “This decision is deeply frustrating, and to diverge from a UK-wide scheme shows that it is not one made with the best interests of Welsh consumers and producers at its core.
“The UK market is so interlinked that any decision which places Welsh businesses at a competitive disadvantage should not proceed. These calls from a range of industry and business representatives have been ignored by the Welsh Government.
“For the sake of our businesses and consumers, I urge the Welsh Government to reconsider its decision, align itself with the UK-wide scheme, and provide proper support to Welsh businesses.”
Industries, especially the micro-brewery sector, would be especially hit hard in Wales by the Welsh Governments choice.
Speaking following this announcement, Richard Johnson, Head Brewer at Tenby Harbour Brewery said:
“The brewing industry has had to tread a path through covid lockdowns, energy price increases, a cost of living crisis and rising wage and national insurance bills, making it increasingly difficult for brewers get good returns and re-invest in their businesses.
“Wales is a recycling nation, so a blunt ‘one size fits all’ approach creates additional logistical and financial burdens on the smallest producers, when the very largest producers are generating the majority of the recycling demand.
“It also seems illogical to diverge away from a UK wide scheme which will put Welsh brewers and drinks producers at a disadvantage.
“The UK and Wales has a proud brewing heritage, but adding in measures such as DRS to small brewers means that their time and money are directed to these activities, instead of using their time for innovation and R&D, of which the UK brewing scene is known and revered for.”
Business
Bluestone crowned ‘Best Small Company for UK Parks and Lodge Holidays’
BLUESTONE is celebrating a major win after being named the Best Small Company for UK Parks and Lodges Holidays at the prestigious British Travel Awards 2024.
The announcement was made at the prestigious awards ceremony this week, marking yet another significant achievement for the popular West Wales destination.
This award recognises Bluestone’s commitment to providing exceptional family holiday experiences at its 500-acre resort in the stunning Pembrokeshire Coast National Park.
“We are absolutely thrilled to receive this award,” said Bethan Rees, Head of Marketing at Bluestone. “It’s a testament to the hard work and dedication of our entire team, who create magical and memorable experiences for families all year round. We are incredibly grateful to every single one of our guests who voted for us and who choose to visit us year on year.
“When you look at the array of other finalists, the award demonstrates why we’re so proud of winning it. This is due to our continued investment, team, and commitment to environmentally sustainable tourism.”
This award builds on Bluestone’s impressive track record. It has consistently received high praise for its family-friendly facilities, commitment to sustainability, and dedication to providing outstanding customer service. Earlier this year, Bluestone was again recognised by Which? as one of the UK’s top holiday destinations and the best rated in Wales.
The British Travel Awards are the largest consumer-voted awards programme in the UK. Winning this award highlights Bluestone’s position as a leader in the family holiday market and reinforces its reputation as a top choice for unforgettable family getaways.
Bluestone, which employs over 800 people and is one of the largest employers in West Wales, is also committed to investing in its people and local community. It provides extensive training and development through its People Services team and the Bluestone Academy. In addition, it supports a wide range of local projects and initiatives through the Bluestone Foundation.
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