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Health

New rapid TB diagnosis detector to be developed in west Wales

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WELSH researchers have been awarded funding of almost £1.2 million to develop a new detector for tuberculosis in humans and animals that can report a result in one hour.

The technology will be simple enough to be operated by any healthcare worker or veterinarian. It will be more specific and more sensitive than existing methods as well as significantly quicker than other types of tests.

Supported by funding from UKRI, the project brings together experts in tuberculosis, veterinary medicine, microbiology, microwave and photonic engineering, to develop a new solution to this global health problem.

TB is a major cause of suffering and death in humans and animals worldwide and is the second leading infectious killer of humans after COVID-19. There are currently around 10 million recorded human TB infections per year, with a death rate of 1.8 million per year.

The lack of a rapid accurate diagnosis, particularly in poorer nations, often leads to misdiagnoses and ineffective treatment of TB patients.

Professor Glyn Hewinson, Sêr Cymru research chair in the Centre of Excellence for Bovine Tuberculosis at Aberystwyth University, said: “The impact of TB is devastating, so developing a rapid diagnosis method could be truly transformative. Eliminating the human TB epidemic by 2050 is a key UN Sustainable Development Goal, and the World Health Organization highlights the need for more effective rapid diagnostic tests as a critical step. We are looking forward to working with our colleagues in Cardiff to make advances in this important area of research.”

The high prevalence of TB in cattle in parts of the UK has a major effect on both the livelihoods and wellbeing of farmers. The surveillance, diagnostic testing, badger culling and vaccination costs the UK government alone a total of £100 million per year.

Professor Les Baillie, Professor of Microbiology at the School of Pharmacy and Pharmaceutical Sciences at Cardiff University, and co-lead on the project said:

“Tuberculosis is a particular problem for farmers in Wales who have seen bovine TB decimate herds across the country. Diagnosis of the early stages of infection is challenging due to the lack of rapid, accurate tests.

“To address this, we are working with colleagues from Aberystwyth University to advance the development of a real-time test capable to detecting the presence of the pathogen in clinical and environmental samples.”

Aberystwyth experts will lead on the development and evaluation of an optical device which will for the first time attempt to solve issues with sample impurities and sensitivities.

Professor Nigel Copner, Head of the Business School and Academic Lead for the Engineering Unit at Aberystwyth University said:

“PCR testing is the gold standard for detecting pathogens but requires special processing for high sensitivity. However, most detection methods struggle with sample impurities.

“Using techniques developed in Cardiff, the photonics team at Aberystwyth University has innovated a method that enables high sensitivity detection directly from on-site samples, without needing time-consuming purification. If successful, this technique could achieve near-PCR sensitivity at the point of sampling, potentially revolutionising pathogen pandemic management.”

Further investment in the project will allow the new technology to be reduced in both size and cost to create a simple, low-cost detector, which will have particular benefit for use in developing countries.

The platform can be easily adapted to detect most other pathogens, including SARS-CoV-2 and MRSA, and could become an important tool to help control the spread of future pandemics.

The project is being funded by the UKRI cross research council responsive mode (CRCRM) pilot scheme, which is supporting new and creative interdisciplinary ideas emerging from the UK’s research community. The project has been awarded £1,199,669 and is one of 36 projects being funded by the £32.4 million UKRI CRCRM scheme.

Health

Hospital visiting precautions in place ‘to protect patients’

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VISITORS to hospitals across Carmarthenshire, Ceredigion, and Pembrokeshire are being asked to only attend if they are free of any potential flu-like symptoms, or any sickness or diarrhoea. Additionally, they may be requested to wear face masks before entry to certain wards or departments.

Seasonal flu and winter vomiting viruses are affecting patients on several wards with infection prevention and control actions being taken, as necessary.

Visitors are asked to only come to see their loved ones if they are free of any infections, to wash hands before leaving home and clean hands on arrival at the hospital/ward using the hand sanitiser. Visitors may also be asked to wear face masks/coverings on the ward/department they are visiting. Masks will be available at the hospital entrance or can be provided on affected wards.

There are additional restrictions in place that limit visitors to:

Acute Medical Assessment Unit (AMAU) at Prince Philip Hospital, Llanelli. Please discuss individual patient visiting arrangements at AMAU with the nurse in charge.
This arrangement will be reviewed daily, and restrictions will be lifted as soon as possible. The health board’s website will be updated daily with details of wards with enhanced restrictions on visiting.

Janice Cole Williams, Assistant Director of Nursing at Hywel Dda University Health Board
said: “Within affected wards, all staff are wearing masks and visiting is limited at Prince Philip Hospital’s AMAU to help stop spread of infection.

“Our local community can help us avoid outbreaks of infection by not visiting family and friends in hospital if they are feeling unwell themselves.

“Annual flu vaccination is also undoubtedly the best way to protect against catching or spreading flu. Not only can it prevent you from becoming very unwell, it can also help reduce your risk of secondary infections such as pneumonia, which can be dangerous if you are clinically vulnerable.”

Vaccination centres are open, with no appointment needed today (Monday), until 5.30pm and tomorrow, Tuesday, December 31 for all people eligible for flu and COVID-19 vaccinations. This includes children aged two years (on 31 August 2024) to those in year 11 who can access the nasal flu vaccine at the centres.

Drop in any time between 9.15am and 5.30pm to your nearest vaccination centre:

Aberaeron (Aberaeron Integrated Care Centre, Vicarage Hill, Aberaeron, SA46 0DY)
Llanelli (Unit 2a, Dafen Industrial Estate, Heol Cropin, SA14 8QW)
Neyland (Unit 1 Honeyborough Retail Park, SA73 1SE)
The following groups are eligible for vaccination:

Flu vaccination

Children aged two and three years on 31 August 2024 
Children in primary school from reception class to year 6 (inclusive)  
Children in secondary school from year 7 to year 11 (inclusive)   
People aged six months to 64 years in clinical risk groups   
People aged 65 years and older (age on 31 March 2024)   
Pregnant women  
Carers aged 16 and over 
People aged six months to 65 years who live with someone who has a weakened immune system   
People with a learning disability  
Frontline health and social care workers  
All staff working in care homes with regular client contact
Poultry workers at high risk
COVID-19 vaccination

People aged six months to 64 years with a long-term health condition (which includes pregnant women and people with a weakened immune system)
Residents in a care home for older adults
People aged 65 years and older (age on 31 March 2025)
Unpaid carers
Frontline health and social care workers
Staff working in care homes for older adults
If you have any questions about accessing the flu and/or COVID-19 vaccine, please phone the health board on 0300 303 8322 option 1 or email: [email protected]

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Community

Milford Haven mum gives birth to triplets amid medical emergency

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PREGNANCY is often a challenging experience, but for Ellie Davies from Milford Haven, it became even more stressful when she found herself facing a 140-mile round trip away from home during labour.

Ellie was initially admitted to Carmarthen’s Glangwili Hospital with pre-eclampsia, a condition causing dangerously high blood pressure. However, due to a lack of available neonatal intensive care unit (NICU) beds, staff arranged her transfer to Singleton Hospital in Swansea, nearly 30 miles away. Thankfully, accommodation was also provided onsite for her fiancé, Craig Butland.

RENAL FAILURE COMPLICATIONS
Ellie explained: “I had pre-eclampsia and was taken to Glangwili. My blood pressure was going up and down, and they had to ring around hospitals with a NICU to see if they had any spare beds – Singleton was the only one with space.”

On November 12, Ellie was transferred to Swansea, where she remained on the antenatal ward. However, her condition worsened. “On Sunday 17, my kidneys became affected by the pre-eclampsia, and I was going into renal failure,” she said.

In the early hours of Monday, November 18, Ellie underwent an emergency C-section, delivering triplets Mia, Isla, and Elsie two months prematurely.

BRIEF FIRST MEETING
“I only met Isla, the middle triplet, for around two minutes before she was taken to neonatal to be with her sisters,” Ellie shared.

Mia was born weighing 2lb 9oz, Isla at 2lb 10oz, and Elsie at 2lb 8oz. All three girls initially required breathing support and spent nine days in the NICU. Now, over three pounds each, they are receiving care at Glangwili’s special care unit and are reportedly “doing really well.”

SUPPORT FROM NHS STAFF
Reflecting on their experience, Ellie praised the hospital staff: “The midwives Louise and Emily were amazing, answering every question we had and supporting us through everything. Dr Sree Nittur, who was there during the delivery, followed up daily. The neonatal nurses were absolutely fantastic, and we can’t thank them enough for their care and dedication.”

A PLACE TO STAY
For Craig, the availability of accommodation at Cwtsh Clos, a row of five houses on the Singleton Hospital site, was a significant relief. Without it, he would have faced daily commutes between Milford Haven and Swansea.

“Craig spent a week in Cwtsh Clos, and I joined him for the final night,” Ellie said. “It was a huge help having Craig so close. It’s one problem you don’t have to think about, and it gives you a space to gather your thoughts.”

The couple is now supporting Swansea Bay Health Charity’s Cwtsh Clos appeal, which aims to raise £160,000 to refurbish the homes for future families in similar situations.

‘TRIPLETS ARE A RARITY’
Lisa Harris, interim matron for neonatal services, said: “We are delighted to hear the girls are doing well. Cwtsh Clos allows parents to stay close to their babies, which is so important during such critical times.”

NICU consultant Kate Burke added: “Triplets are a rarity for us. We serve families across south central and south west Wales, and often, we’re the unit they turn to when pregnancies are more complicated. It’s wonderful to see families like Ellie and Craig’s returning home with their babies healthy and thriving.”

The family recently celebrated their first Christmas together with Mia, Isla, and Elsie, expressing heartfelt gratitude to all who supported them through their journey.

Support the Cwtsh Clos Appeal: Donations can be made via the Swansea Bay Health Charity website.

(Pic: Swansea Bay University Health Board)

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Charity

£3,800 donated to services across Withybush Hospital

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THE CAMROSE VINTAGE WORKING DAY team has donated £3,800 to services across Withybush Hospital.

Their 37th annual event raised a record breaking £25,000, which has now been distributed among 26 local charities.

They donated the funds to the Stroke Ward, Specialist Respiratory Team, Chemo Day Unit and Heads Up! Hair Loss Initiative at Withybush Hospital. Each service received £950.

The Heads Up! initiative provides a person-centred, holistic hair loss service for cancer patients. It brings together healthcare and haircare professionals from local communities to give patients the knowledge and products needed to manage their hair loss with dignity and choice.

Katie Hancock, Fundraising Officer, said: “Thank you to Andrew, the team and the supporters of the Camrose Vintage Working Day for your generosity once again. Your donation to each service is amazing and will make a big difference. We are hugely grateful for your wonderful support.

“The support of our local communities enables us to provide services over and above what the NHS can provide in the three counties of Hywel Dda and we are extremely grateful for every donation we receive.”

Pictured above: Andrew James, Chairman of Camrose Vintage Working Day with Withybush Hospital staff from the Stroke Ward, Specialist Respiratory Team, Chemo Day Unit, Heads Up! Hair Loss initiative.

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