News
Reprogrammed virus offers hope as cancer treatment
A CANCER treatment that can completely destroy cancer cells without affecting healthy cells could soon be a possibility, thanks to research led by Cardiff University.
The team of researchers has successfully ‘trained’ a respiratory virus to recognise ovarian cancer and completely destroy it without infecting other cells. The reprogrammed virus could also be used to treat other cancers such as breast, pancreatic, lung and oral.
Dr Alan Parker from Cardiff University’s School of Medicine said: “Reprogrammed viruses are already being used in gene therapy procedures to treat a range of diseases, demonstrating they can be trained from being life-threatening into potentially lifesaving agents.
“In cancer treatment, up until now, reprogrammed viruses have not been able to selectively recognise only the cancer cells and would also infect healthy cells, resulting in unwanted side effects.
“We’ve taken a common, well-studied virus and completely redesigned it so that it can no longer attach to non-cancerous cells but instead seeks out a specific marker protein called αvβ6 integrin, which is unique to certain cancer cells, allowing it to invade them.
“In this case we introduced the reprogrammed virus to ovarian cancer which it successfully identified and destroyed.
“This is an exciting advance, offering real potential for patients with a variety of cancers.”
Once the virus enters the cancer cell it uses the cell’s machinery to replicate, producing many thousands of copies of itself, prior to bursting the cell and thereby destroying it in the process. The newly released viral copies can then bind and infect neighbouring cancer cells and repeat the same cycle, eventually removing the tumour mass altogether.
The virus also activates the body’s natural immune system, helping it to recognise and destroy the malignant cells.
The reprogrammed virus is from a group of respiratory viruses called adenoviruses. The advantage of using these viruses is that they are relatively easy to manipulate and have already been safely used in cancer treatment.
The technique used to reprogramme the virus to identify the protein common to ovarian, breast, pancreatic, lung and oral cancers could also be used to manipulate it so that it would recognise proteins common to other groups of cancers.
Additional refinement to the viral DNA could also allow the virus to produce anticancer drugs, such as antibodies, during the process of infecting cancer cells. This effectively turns the cancer into a factory producing drugs that will cause its own destruction.
The research was carried out in a laboratory, using mice with ovarian cancer, and has not yet reached clinical trials. The next step is to test the technique with other cancers, with a view to starting clinical trials in five years’ time.
Dr Catherine Pickworth from Cancer Research UK said: “It’s encouraging to see that this virus, which has been modified to recognise markers on cancer cells, has the ability to infect and kill ovarian cancer cells in the lab. Viruses are nature’s nanotechnology and harnessing their ability to hijack cells is an area of growing interest in cancer research.
“The next step will be more research to see if this could be a safe and effective strategy to use in people.”
The team includes researchers from Cardiff University; the Mayo Clinic in Rochester, USA; Glasgow University; the South West Wales Cancer Institute; and Velindre Cancer Centre.
The research was funded by Cancer Research UK, Tenovus Cancer Care and Cancer Research Wales.
The paper ‘Ad5NULL-A20 – a tropism-modified, αvβ6 integrin-selective oncolytic adenovirus for epithelial ovarian cancer therapies’ is published in Clinical Cancer Research.
Education
Leadership questions raised after Milford Haven school stabbing
Headteacher absent as council confirms support plan and oversight visits
CONCERNS have been raised about leadership and staffing at Milford Haven Comprehensive School following last week’s alleged stabbing of a teacher on site.
The Herald has been contacted by a member of teaching staff who described the school as “rudderless” in the days after the incident and questioned whether enough senior management support was in place.
The teacher, who asked not to be named, said staff morale had been affected and claimed there had been little direct communication from the headteacher, who has been absent due to injury.
They said: “We teachers are all saying the same thing. The school feels rudderless. This is a time when a leader needs to step up and let us know they’re still in charge and concerned.”
Concerns were also raised about administrative capacity, with the business manager role reportedly unfilled.
A spokesperson for Pembrokeshire County Council confirmed the current arrangements.
The council said headteacher Ms C. A. Morris remains in post but is currently absent, with deputy headteacher Mr Daryl John deputising.
It added that the business manager position is a matter for the school.
Additional support has been put in place for staff and pupils, including the Education Psychology team on site, access to counselling services and an increased presence from the School Police Liaison Officer throughout the week.
The authority also said the Director of Education is in daily contact with the deputy head.
In terms of oversight, the council confirmed Steven Richards-Downes, Director of Education, has visited the school 35 times and met staff on two occasions. Cllr Guy Woodham, Cabinet Member for Education and Welsh Language, has made eight visits since taking up the role in May 2019.
Last week’s incident saw a 15-year-old male charged grievous bodily harm with intent and possession of a bladed article.
At an initial hearing it was explained that the teacher, who was named as Vicky Williams, has since been discharged from hospital.
The prosecution explained to the court that the boy attacked Williams with a kitchen knife.
The case has been sent to Swansea Crown Court.
Community
Facebook ‘news’ site targeting Herald editor collapses after community backlash
Page disappears hours after offensive post sparks outrage across Pembrokeshire
A FACEBOOK page that presented itself as a local news outlet but repeatedly targeted The Pembrokeshire Herald and its editor has disappeared following a wave of public criticism from residents and charity workers.

The page, operating most recently under the name Clear Line News, published a lengthy post on Sunday (Feb 9) describing Pembrokeshire in highly offensive terms and mocking community groups, volunteers and local reporting.
Within hours, the post triggered widespread condemnation online.
By the end of the day, users reported the page had changed its name to “The Devil’s Feed” before becoming unavailable altogether.
Criticism arose after Marty Jones, PR manager for Sandy Bear Children’s Bereavement Charity, shared a screenshot of the post on his personal Facebook page and questioned its tone.
Dozens of residents replied, describing the language as “vile”, “nasty” and “beyond comprehension”.
Several said they had been blocked by the page after challenging it.
Others expressed particular anger at comments they said were directed towards a bereaved mother connected to a local fundraiser.
One commenter wrote: “How they can speak to a bereaved mother that way is beyond my comprehension.”
Name change and closure
As criticism mounted, users reported the page had been renamed before disappearing completely.
By Monday morning, it could no longer be accessed.
Earlier identity
The page’s history has also drawn scrutiny.
Before operating as Clear Line News, the account previously used the name “Dyfed-Powys Neighbourhood Watch”, presenting itself in a way that some residents believed suggested an official or community safety organisation.

A company using a similar name — GWARCHOD Y GYMDOGAETH DYFED-POWYS NEIGHBOURHOOD WATCH LIMITED — was incorporated on Nov 4, 2024, according to Companies House records.
The filing listed the director as Ajay Owen, recorded as “Lord Ajay Owen”, with a correspondence address in Llanfyrnach.
The company’s stated activities included public relations, communications and public order and safety functions.
Companies House records show the company was dissolved on Feb 18, 2025.
During the period when the page appeared to carry Neighbourhood Watch-style branding, it accumulated more than 1,000 followers, including engagement from public bodies such as Mid and West Wales Fire and Rescue Service.
After several rebrands, the page later emerged as Clear Line News in late 2025, adopting the look of a local news site.
Much of its content, however, focused on opinion pieces and attacks on local institutions and individuals.
Distancing statement
Following Sunday’s controversy, Mr Owen posted a statement saying he previously owned the page but no longer controlled it and had requested its removal.
Shortly afterwards, the account disappeared.
He told The Herald in December that he had sold the page for £10 within days of relaunching it under the new name. The purported new owner could not be contacted and no independent details confirming the transfer were provided.
Community response
While Pembrokeshire residents accept robust debate and scrutiny, many said they rejected what they saw as inflammatory or abusive social media content masquerading as journalism.
One resident wrote: “We should be grateful for where we live and try to make it better, not tear it down.”
Whether the page returns under another name remains unclear.
For now, it appears a site that set out to criticise the community ended up undone by that same community’s response.
Community
Nacro grant boosts neurodiverse support in Carmarthen
A £1,000 grant from Nacro is set to strengthen grassroots support for neurodivergent children, young people and adults across Carmarthenshire.
CANDO (Carmarthen Aberystwyth Neurodiverse Outreach Group) has secured the funding through the Connecting Carmarthenshire Preventative Service, enabling the volunteer-led organisation to expand its practical, person-centred work with local families.
Operating under the message “We see your future whatever the past”, CANDO supports people who often struggle to access the right help, feel heard, or find stability in everyday life. The new funding will increase capacity, provide resources for inclusive sessions, and improve access to early support for those who might otherwise slip through the net.

The group works closely with individuals and families to reduce barriers and build confidence — whether through education guidance, wellbeing support, advocacy, or help navigating local services. Leaders say the grant will allow them to respond more quickly to growing demand and keep sessions welcoming, accessible and consistent.
A CANDO spokesperson said: “This grant is amazing news for our community. Neurodivergent people can face extra pressures — from isolation and anxiety to difficulties being understood in education and services. This support will help us reach more people, provide practical help, and keep showing up for those who need someone on their side.”
Nacro’s wider mission mirrors that approach. The charity works across education, housing, justice, health and wellbeing, providing tailored support to help people build independence and move forward. Alongside frontline services, it also campaigns to remove systemic barriers and give disadvantaged people a stronger voice.
For CANDO, that bigger picture is felt locally. Families often face complicated pathways, long waits and fragmented services, and need clear guidance and community-based help that understands neurodiversity. By intervening early — before challenges escalate — the group believes it can improve mental health, education outcomes and overall wellbeing.
The £1,000 grant will fund additional outreach, materials and practical resources, helping more people feel safer, more confident and better equipped to move forward.
CANDO added: “We’re proud to work alongside Nacro’s vision of a society where everyone has the chance to succeed. This funding will do real good — right here in Carmarthen and beyond — and we’re grateful for the belief it shows in our community.”
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