Health
Research solves pancreatic cancer mystery

A NEW technique to study tissue samples in 3D has revealed that pancreatic cancers can start and grow in two distinct ways, solving a decades-old mystery of how tumours form.
The new method could help researchers to get more information from tissue biopsies and may lead to improved treatments for pancreatic cancers. The technique was developed by scientists at the Francis Crick Institute, and their results are published in Nature. The work was supported by the European Research Council and core funding from the MRC (one of the Crick’s founding partners).
The pancreas is a crucial organ that sits behind our stomach and plays a key role in digestion. It relies on a network of ducts linking it to other digestive organs, and the most common pancreatic cancers are found in the ducts. However, until now it has only been possible to see 2D slices of these ductal cancers, which contained an unexplained variety of abnormal shapes.
“To investigate the origins of pancreatic cancer, we spent six years developing a new method to analyse cancer biopsies in three dimensions,” explains Dr Hendrik Messal from the Francis Crick Institute, co-lead author of the research paper. “This technique revealed that cancers develop in the duct walls and either grow inwards or outwards depending on the size of the duct. This explains the mysterious shape differences that we’ve been seeing in 2D slices for decades.”
By analysing developing cancers in 3D, the team defined two distinct types of cancer formation: ‘endophytic’ tumours which grow inwards and ‘exophytic’ tumours which grow outwards. To find out what makes cancer cells grow in a particular way, they analysed detailed 3D images and worked with biophysicists at the Crick who created sophisticated computer models.
“We made a simulation of the ducts, describing individual cell geometry to understand tissue shape,” explains biophysicist Dr Silvanus Alt, co-lead author of the paper. “The model and experimental results both confirmed that cancer grew outwards when the diameter of the duct was less than approximately 20 micrometres, around a fiftieth of a millimetre.”
The work was made possible by an interdisciplinary collaboration between two research groups at the Crick, led by Dr Axel Behrens and Dr Guillaume Salbreux. Axel’s group works on stem cells and pancreatic cancer, while Guillaume focuses on using physics to understand biological processes.
“I think we first started discussing this when we bumped into each other in the bike shed,” says Axel. “It’s amazing what can come out of a chance encounter, we now have a patented technique to see the three-dimensional shapes of cancers and a biophysical understanding of the emergence of tumours. Now that we know pancreatic cancer can develop in these two different ways, we can start looking at whether one is likely to be more aggressive or spread in a different way. Many years from now, this could lead to improved diagnostic or treatment options.”
The team also applied the technique to other organs and found that cancers in the airways of the lungs and ducts in the liver behave in the same way. This shows that the mechanism the teams discovered is not specific to the pancreas and also applies to other cancers.
“Both the data and our models indicate that the two different mechanisms of tumour growth are purely down to the innate physics of the system,” explains Dr Guillaume Salbreux. “Like most cancers, ductal pancreatic cancer starts with a single defective cell that starts dividing. We found that very quickly, when there are only a few cells, the tumour has already started to grow either inwards or outwards depending on duct diameter. Defining this fundamental process will help us to better understand how cancer grows in many places across the body.”
Dr Mariana Delfino-Machin, Programme Manager for Cancer at the MRC, said: “Pancreatic cancer remains a very difficult disease to treat but understanding that it can grow in different ways will inform the development of more accurate treatments in the future.
“These findings came about thanks to researchers working in very different fields coming together to successfully tackle the same problem.”
Health
Eye care services ‘woefully under-resourced’

TENS OF thousands of people at the greatest risk of irreversible sight loss are languishing on waiting lists for too long, with services woefully under-resourced, a committee heard.
The Senedd’s health committee took evidence from clinicians, charities and patients as part of a short inquiry into ophthalmology in Wales on March 20.
More than 80,000 patient “pathways” – which include those waiting for multiple treatments – were waiting too long for sight-saving treatment in January, according to the latest data.
Russell George, who chairs the health committee, asked about prevention given half of all sight loss is avoidable with early detection and timely treatment.
Ansley Workman, director of the Royal National Institute of Blind People (RNIB) Cymru, welcomed a new national clinical strategy but warned of a lack of commitment.
“There’s no investment, there’s no timeline,” she said: “And that timeline needs to be at pace and the reason for that is people are going blind in Wales now, so it is a matter of urgency.”
In its written evidence, RNIB Cymru voiced concerns about the lack of a significant investment and direction from ministers in Cardiff Bay.
The charity warned: “Without this, Wales’ eye care waiting lists will continue to rise as will the number of patients … needlessly losing their sight while waiting for NHS treatment.”
Ms Workman raised underreporting of the scale of harm befalling patients in Wales, with “shockingly low” reports despite 80,000 patient pathways being over their clinical target.
Senedd Members heard powerful stories from patients who shared their frightening experiences of living in constant fear of losing their sight.
Rhianon Reynolds, clinical lead for ophthalmology within the NHS Wales Executive, pointed to the development of the national strategy but warned of a lack of support to drive change.
The consultant ophthalmologist said: “We can put the blueprint in place but without investment … it’s going to be difficult to show significant change.”
Ms Reynolds, who is president of the Royal College of Ophthalmologists in Wales, told Senedd Members that ophthalmology is the biggest outpatient speciality in the NHS.
But she said: “We are often perceived as a small speciality because we don’t have inpatients, so … we’re often not overly prioritised in terms of how we are funded.”
Ms Reynolds warned: “In terms of consultant ophthalmologists we are woefully under-resourced in Wales right across the board. Some areas are like a desert.”
She added: “Even if we had more secondary care clinicians, we don’t have the space.”
Ms Reynolds, who works at Aneurin Bevan health board, raised “fundamental problems” with the estate, citing examples of ceilings falling in and plants growing through the walls.
On the £8.5m roll-out of the OpenEyes patient record system, which began in 2021, she explained that Digital Health and Care Wales (DHCW) is responsible for the project.
She told the committee: “We don’t have it across all the health boards, it’s available in Cardiff, it’s potentially being rolled out to other health boards.”
Last week, health secretary Jeremy Miles escalated intervention arrangements at DHCW due to serious concerns about its ability to deliver major programmes.
Asked if roll-out of OpenEyes is being prioritised, Ms Reynolds said: “No, I don’t think it is.”
She told the committee a digital transformation is required, saying: “It’s a huge area of frustration for us,” with services still receiving letters rather than digital referrals.
Ms Reynolds said Wales is well below the Royal College’s recommendation of 3.2 ophthalmologists per 100,000 people, with around 1.9.
“In terms of the consultant workforce, we’re extremely under-resourced,” she warned, adding that there is not a much-needed workforce plan in place.
Wales has the lowest numbers of consultant ophthalmologists of any part of the UK and, across Europe, only North Macedonia has fewer, according to the RNIB’s evidence.
Owain Mealing, chair of Optometry Wales, warned of “clunky” integration between primary optometry and hospital services, with fax machines and paper records still in use.
Andrew Pyott, a consultant ophthalmologist at NHS Highland, undertook a 2021 review on eye care services in Wales which described the situation as serious and fragile.
He said: “The biggest driver is for cataracts services, that’s what patients often see as a priority for them – many who are languishing on long waiting lists, with an impact on their daily lives because they can no longer drive or, in some cases, keep down employment.”
Asked about agreements for patients to be treated in England, he told the committee that Welsh taxpayers are effectively subsidising Bristol’s training programme.
Prof Pyott said: “It would be much better for the Welsh taxpayer to be preparing the next generation of vitreoretinal surgeons for your country.”
Health
Ministers at odds with dentists over ‘biggest reforms in decades’

WALES’ health secretary set out plans for the biggest changes to NHS dentistry services in almost two decades despite still being at loggerheads with the profession.
Jeremy Miles said the Welsh Government will launch a consultation on dentistry reforms, which will mark a significant change to the old 2006 contract, by the end of the month.
In a statement on March 18, Mr Miles told the Senedd the new general dental services contract will be implemented rom April 2026.
Describing the reforms as the biggest in nearly 20 years, the health secretary said the central aim will be to make it easier to access NHS dentistry.
But, in an open letter last month, the British Dental Association (BDA) accused the Welsh Government of “spin, half-truths or doublespeak” on the future of dental services.
Mr Miles warned of issues with the current model, which is based on the “treadmill” of units of dental activity, saying substantive contract reform is required.
He said instead of recalling everyone every six months for a routine check-up, the new contract will be based on prevention and needs-based provision of treatment.
Negotiations between ministers, the NHS and the BDA over more than a year to design and develop the new contract ended without full agreement.
Mr Miles told Senedd members: “As is the case in all negotiations, there are aspects that all parties can readily agree on; there are some points that may be more contentious. Not everyone gets everything that they want but it is an improvement for everyone.”
He said key aspects of the reforms include:
- creating a single route of entry for people to access NHS services;
- implementing a ‘fairer, more transparent’ remuneration system;
- disincentivising unnecessary routine examinations;
- adjusting patient charges; and
- making changes to terms and conditions, such as around parental leave.
Urging people to have their say as part of the consultation, which he suggested will open next week, Mr Miles said: “It’s one of the biggest changes, probably the biggest change in dentistry within the NHS in coming up to close to a quarter of a century.”
James Evans, the Conservatives’ shadow health secretary, told the Senedd that 189 NHS dentists, or about 13% of the workforce, have left the service in Wales since 2022.

He said the BDA has warned 2025 could see the largest number of contracts handed back in history, with more dentists reducing NHS commitments due to financial pressures.
Mr Evans compared a 6% contract uplift, which the BDA has described as a real-terms cut following the “flawed” negotiations, with an 11% increase for GPs.
“NHS dentistry is in crisis,” he said. “Patients are paying more while receiving less. Dentists are leaving in record numbers and practices are struggling to stay afloat.”
Mr Miles claimed the reforms have been broadly backed by the profession, with eight in 10 practices taking up the offer of a contract variation since 2022.
He said he was not prepared to wait any longer after talks broke down, taking a unilateral decision earlier this year to implement the 6% increase to contract payments.
Mabon ap Gwynfor raised the BDA’s warning of a dental desert spreading across the country, with a rise in so-called DIY dentistry and an increasingly disaffected workforce.

The Plaid Cymru politician accused the Welsh Government of ploughing ahead on a road to ruin and turning a blind eye to a rapidly unfolding crisis in the sector.
Warning dentists have been kept in the dark since September, Mr ap Gwynfor said: “On the one hand, this government says that it is unlocking hundreds of thousands of extra appointments but the BDA accuses them of cooking the books.”
Health
RCN demands Cardiff University protect nursing education

Don’t scrap top-ranked nursing degree, union urges
RCN WALES has strongly opposed Cardiff University’s proposal to close its School of Nursing, warning of serious consequences for students, staff, and patient care.
The Royal College of Nursing (RCN) expressed deep concern in its formal response to the university’s internal consultation, criticising the lack of prior engagement before the announcement. The union described the proposal as a threat to nurse academics, student members, and the wider public.
A petition urging the Senedd to intervene and preserve the university’s nursing courses has already gathered over 7,300 signatures from across Wales. The potential closure comes as Wales faces a critical shortage of nurses, with around 2,000 NHS vacancies and an increasing reliance on corridor care, where patients are treated in unsuitable and sometimes unsafe areas. The RCN warns that shutting down the programme would worsen these challenges and put patient safety at risk.
The move would also damage Cardiff’s reputation as a centre of excellence for nursing education. The university has provided nurse training since 1972 and is ranked 1st in Wales, 5th in the UK, and 51st globally for nursing. As a member of the prestigious Russell Group, Cardiff plays a vital role in developing Wales’ healthcare workforce.
Helen Whyley, Executive Director of RCN Wales, said: “This proposal is profoundly alarming. Either Cardiff University’s leadership does not recognise its proud legacy in nurse education or believes this is a price worth paying.
“How Cardiff University can claim that its nursing programmes are unsustainable when they are funded by the Welsh Government is baffling. The university should immediately withdraw these proposals, commit to no compulsory redundancies, and instead work with key stakeholders, including the RCN, to find a solution that safeguards nursing students, academic staff, and patients.”
She added: “We remain committed to working with Cardiff University to secure the future of nurse education in Wales.”
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