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Health

Gene study on depression’s origins

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HUNDREDS of genes have been newly linked to depression, shedding light on the origins of the condition and highlighting personality types that could be at risk.

The international study, involving more than two million people, is the largest of its kind. It could inform treatments for the condition, which affects one in five people in the UK and is the leading cause of disability worldwide.

Scientists led by the University of Edinburgh studied information pooled from three large datasets of anonymised health and DNA records and pinpointed 269 genes that were linked to depression.

They also used an innovative statistical method to identify sections of DNA that were common in people with depression and in those who adopted lifestyle behaviours such as smoking.

The findings suggest that depression could be a driving factor leading some people to smoke, but more research is needed to explain why, the team says.

Results also show that neuroticism – a tendency to be worried or fearful – could lead people to become depressed, which could shed light on personality factors that put people at risk. The statistical approach – known as Mendelian randomisation – allows scientists to look at how a condition impacts on behaviour, while ruling out other influences such as age or income.

Anonymised data, used with donor consent, is held by UK Biobank, the personal genetics and research company 23andMe and the Psychiatry Genomics Consortium.

Experts say that the study reflects the importance of data science in understanding mental health.

The study, published in Nature Neuroscience, was funded by the MRC and Wellcome.

Professor Andrew McIntosh, of the University of Edinburgh’s Centre for Clinical Brain Sciences, who led the research, said: “These findings are further evidence that depression is partly down to our genetics.

“We hope the findings will help us understand why some people are more at risk of depression than others, and how we might help people living with depression and anxiety more effectively in future.”

Sophie Dix, Director of Research at mental health charity MQ, who was not involved in the research, said: “This study adds to the weight of evidence that genes are one of the key risk factors in depression, which is also impacted by life events such as social environment and trauma. The value of this could really be seen when looking into the development of personalised treatments – a welcome step, given the dearth of innovation in identifying new approaches. We have seen very little advancement in nearly 50 years for people living with depression and right now the avenues available are not working for everyone.

“The power of this big genetic study is that it can point to systems in the brain which adds to our currently limited understanding in this area. By increasing our understanding of these systems, and how the social environment affects biological risk factors, we can begin to identify new targets for treatments that could help the millions of people worldwide affected by depression.”

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Health

Chairman opens new NHS 111 Wales Service Centre in Haverfordwest

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IN a ceremonial occasion on Thursday (May 2), Thomas Baden Tudor, Chairman of Pembrokeshire County Council, inaugurated the new NHS 111 Wales service centre at Haverfordwest Ambulance Station. The event was marked by Mr. Tudor cutting the red ribbon, a task he was honoured to perform at the behest of Matthew Jones, Locality Manager of the Pembrokeshire Ambulance Service.

The NHS 111 service, which is accessible round the clock, offers urgent health advice and information about available services, including dental care and general medical guidance. This vital resource also provides support on managing illnesses and conditions and ensures continuity of care when GP offices are closed.

Speaking at the event, Mr. Tudor expressed his pride and privilege in participating in the launch, which underscores the community’s commitment to enhancing healthcare accessibility. The new service centre is expected to play a pivotal role in providing prompt medical advice and support to the residents of Pembrokeshire.

The service is free and can be reached by dialling 111 from any phone, ensuring essential healthcare advice is just a call away.

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Health

Junior doctors secure strike extension in pay negotiations with WG

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BMA Cymru Wales has confirmed a positive development in its pay negotiations announcing that Junior doctors have secured a three-month extension to their overwhelming strike mandate.

This means that junior doctors in Wales now have the right to enact industrial action over their pay until 17 September 2024 instead of 17 June when the mandate was due to run out.

Recognising the strength of feeling amongst junior doctors and the overwhelming 98% vote by members in favour of industrial action back in December 2023, employers have agreed to honour this extension to allow talks with the Welsh Government to continue.

Co-chairs of the Welsh Junior Doctor Committee Dr Oba Babs-Osibodu and Dr Peter Fahey said of this development:

“We are pleased to be able to secure an extension to our overwhelming strike mandate. Whilst we hope to put an end to our pay dispute through pay negotiations by reaching a credible deal and restoring our pay, it was important to secure more time for our mandate.

“The extension allows us to focus on talks but also provides us with the scope to get organised and enact our legal right to strike should we need to. This is about honouring the emphatic mandate of our members.

“Doctors have experienced real terms pay cut of almost a third since 2008. They voted overwhelmingly to put an end to the devaluing of their service, they know they are not worth a third less than their predecessors and they know the time is now to stick up for the profession and turn the tide of the continued erosion of their pay once and for all”.

The Welsh Government and NHS employers have agreed to the extension as part of ongoing pay negotiations where all parties hope to reach an end to the pay dispute with junior doctors, SAS doctors and Consultants in Wales.

Last month, BMA Cymru Wales announced it was suspending forthcoming industrial action for Consultants and SAS doctors and putting plans on hold to announce more strike dates for junior doctors to allow pay negotiations to take place*.

The decision to enter pay negotiations was based on a significant proposal from the Welsh Government to form the basis of talks to end the pay disputes with all secondary care doctors including Consultants, SAS, and Junior doctors, with the aim of reaching deals which can be taken separately to their respective members.

In August last year, the BMA’s committees representing secondary care doctors in Wales voted to enter separate trade disputes with the Welsh Government after being offered another below inflation pay uplift of just 5% for the 23/24 financial year. SAS doctors on some contracts were offered as little as 1.5%. This was the lowest pay offer any government in the UK offered and less than the DDRB, the pay review body for doctors and dentists, recommended last year.

As part of their disputes, SAS doctors, consultants and junior doctors carried out successful ballots for industrial action. Since then, junior doctors have taken part in 10 days of industrial action since January this year.

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Community

Plea to save at-risk Anchorage day care centre

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AN ONLINE plea to save a Pembrokeshire day centre from being closed has been lodged with the county council.

The Anchorage Day Care Centre in Pembroke Dock has been a “safe and happy place” for adults with learning difficulties and additional needs for decades.

In more recent years it has expanded to support elderly dementia sufferers.

But now the centre is expected to close, with services instead being offered elsewhere in the county, including Haverfordwest and Milford Haven.

A series of engagement events have taken place at The Anchorage recently, outlining the reasons and the options in continued service.

One parent, who wished to remain anonymous, said: “The parents and carers are all very upset at the way we have been treated, kept in the dark and then presented with what is a fait accompli to close the Anchorage, while at the same time going through the motions of a ‘consultation’ with us.

“The clients at The Anchorage have friendships with each other and staff going back decades in some cases.

“One young woman who attends ran out of the first meeting sobbing when she was told it was going to close. Another, at the second meeting, tried to address the meeting but was so chocked up at the thought of not seeing her friends anymore she could hardly speak.”

She added: “The Anchorage has been a respite in the day for parents and a safe, happy place for the clients.

“Everyone feels that the county council is not considering the feelings of the clients, most of whom are upset and frightened by change to their routine.”

Another person raising concerns said: “The centre is set to close as early as next month – meaning the sudden retraction of a service which, for many families in the area, is nothing short of a lifeline.

“I’m not sure PCC understand the gravity of the impact that closing the centre will have on the lives of many people, particularly the customers, some of whom may not understand or cope well with such a total upheaval of the familiarity of their daily routine.

“It’s so upsetting that the people who will be most affected by the closure of the centre are as much a part of the Pembrokeshire community as anybody else that the council claims to represent, and yet in this decision, I feel they’re not being seen as such.”

Since then, an online e-petition, on the council’s own website has been launched calling for it to stay open.

It says: “The centre provides day-care support to a number of vulnerable adults with varying levels of disability who are unable to process, and understand, the implications of such a decision.

“Some of those attending the centre have been doing so for over 20 years and continuity is a vital part of their lives. Removing this service will have nothing other than a huge detrimental impact on their health and mental wellbeing.”

The petition has attracted 284 signatures to date.

A Pembrokeshire County Council spokesman said: “Following the engagement sessions held with families and service users regarding the future of the centre on April 10 and 17 at the Anchorage, families said that they would like to maintain the Anchorage Day Centre and explained that they would write to the council in order to ask for the decision to be overturned.

“People who attend the service will be offered alternative care, all service users are currently having their individual care needs assessed by social work teams to fully understand which other services best meet those care needs.”

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