Revealing the cells behind the biological clocks of intertidal animals
SCIENTISTS in Wales have identified the cells behind the bioclocks keeping time with tides in tiny marine organisms.
The biological clock of land animals is regulated by a circadian rhythm, with biological processes such as sleeping and waking, digestion and hormone release responding to the 24-hour cycle of light and darkness.
Intertidal organisms, on the other hand, regulate their biological processes to a 12.4 hour circatidal clock, which follows the ebb and flow of the tide, in addition to having 24 hour clocks. This allows them to survive in a temporally complex environment which is exposed at low tide and underwater at high tide.

In a paper published today (Thursday 8 May 2025) in Current Biology, researchers at the Medical Research Council Laboratory of Molecular Biology in Cambridge and Aberystwyth University reveal that they have identified the clock cells and genes they think are responsible for this tidal timekeeping.
The discovery marks a significant step forward in scientists’ understanding of how these natural biological clocks are orchestrated at the molecular and cellular level within the brains of intertidal organisms, and could provide insight to the evolution of biological clocks.
The researchers studied two species of crustaceans which inhabit the space between the high and low tide-lines -Eurydice pulchra, the speckled sea louse which is a marine relative of the woodlouse, and the amphipod Parhyale hawaiensis.
By manipulating the light regime that the animals were exposed to, and the maintenance or removal of tidal cues, the researchers were able to disentangle the cells responsible for the circadian and circatidal clocks in the organisms’ brains.
This allowed them to discover that the crustaceans have distinct circadian and circatidal cell groups, which adjust independently to light and to mechanical stimuli (tides).
Dr David Wilcockson, a marine biologist based at Aberystwyth University’s Department of Life Sciences, is a co-author of the paper. He said:
“For more than six decades marine biologists and chronobiologists have known about tidal clocks that regulate the life of coastal animals by studying rhythmic behaviours of numerous marine species. However, significant progress in understanding how these clocks work has been hampered because we have never found the cells that coordinate 12.4 hour behavioural rhythms.
“This discovery is significant because we can now tinker with the clockwork of these cells to better understand the mechanisms that have evolved to keep animals to tidal time. Many of these animals evolved many millions of years before land animals, making the clocks of marine species especially fascinating.”
Chee Ying Sia, a PhD student and joint first-author of the study from the Medical Research Council Laboratory of Molecular Biology in Cambridge, which led the research, said:
“It was exhilarating to identify, for the first time, a small cluster of cells capable of tracking the tidal time in the brains of intertidal crustaceans. These cells might just be the gateway to revealing the mechanisms of tidal timekeeping. The molecular rhythms that we see in these marine animals also hint at clock mechanisms that are different from what we have learned from circadian clocks of terrestrial model organisms.”
The research was funded by the UKRI Medical Research Council and Boehringer Ingelheim Fonds, and was led by Dr Michael Hastings (Cambridge).
Business
House plan for 25-acre Felindre Farchog farmland site
PLANS for a rural enterprise dwelling to support a Pembrokeshire horticultural business are being recommended for approval despite concerns from the local community council.
In an application recommended for approval at the April meeting of Pembrokeshire Coast National Park’s development management committee, Southern Roots Organics/Awen Organics, through agent Preseli Planning Ltd, seeks permission for a rural enterprise dwelling, track extension, and associated works at Eithin Farm, Felindre Farchog, near Nevern.
This application is being presented to the Development Management Committee as local community council Nevern has objected to the application raising material planning matters, contrary to the officer recommendation for approval.
An officer report says Eithin Farm comprises about 25 acres of agricultural land, with an additional seven acres to be rented by the applicants; the applicants running a horticultural business from the site, using multiple polytunnels and employing irrigation systems which require careful management.
The report says the business has been trading for over three years and can support a full-time worker, meeting criteria which addresses planning for sustainable rural communities. The proposal is said to meet these requirements, and the officer’s report confirms a genuine need for the dwelling.
Nevern, in its objection, said: “The living accommodation is supposed to be part of the business, it needs to be closer to the sheds, making the whole enterprise more aesthetically pleasing. The area designated for future seasonal agricultural workers would be an areas that would be more appropriate for a traditional cottage. A restriction on the house, a tied house needs to be considered.”
Objections to the plan have also been received from members of the public raising concerns including foul water disposal and the application “has nothing to do with the new current business”.
However, a number of representations have expressed support for the application. Issues raised include the benefit of applicants living on site, helping to reduce travel and carbon emissions, and confirming support for local, small-scale horticulture, and the contribution the business makes to the community.
The report says there is an identified need for a rural worker’s dwelling, especially due to the need to quickly respond to changes in crop conditions and potential failures in irrigation or ventilation systems.
It concludes: “The evidence submitted with this application, having been assessed by PCNPA’s Agricultural Advisors, is sufficient to demonstrate that an essential need exists for a rural enterprise dwelling, and that the proposal meets the tests set out in [policy].
“The siting and design of the dwelling are considered acceptable with no concerns in relation to landscape impact, amenity or biodiversity. Overall, the proposal is considered to be acceptable and a recommendation to grant permission is made.”
Business
Tenby harbour RNLI building takeaway allowed after appeal
A REFUSED scheme for a takeaway food kiosk at a former lifeboat store in Tenby’s seaside harbour, has now been allowed following a successful appeal.
At the March 2025 development management committee, Ruby Goodrick sought permission from Pembrokeshire Coast National Park planners to turn the old RNLI lifeboat store, Penniless Cove, Tenby Harbour, into a takeaway cold food outlet, open 10am-10pm seven days a week.
The application came before committee members rather than an officer decision as Tenby Town Council objected, and was recommended for approval despite being a departure from the adopted development plan.
However, members voted by 12 in favour to three against approval.
Since then, the applicant lodged an appeal with Planning and Environment Decisions Wales (PEDW), Ruby Goodrick in her statement saying: “The application was refused on the basis that the proposed use is located outside the defined town centre boundary and therefore is contrary [to policies]. However, as outlined in the planning officer’s own assessment, the building is situated approximately 25 metres outside of the defined retail centre and is a use that would otherwise be considered acceptable within that centre.”
It added: “Furthermore, there are already existing local businesses at Tenby Harbour that are allowed to operate without issue. These businesses demonstrate that commercial use in the area, including food-related enterprises, does not adversely affect the surrounding environment or the special qualities of the National Park.”
The Inspector’s report which allowed the appeal, granting permission, focussed on “whether the development would be an appropriate use within this location, the impact on the character and appearance of the area, and whether it would affect Tenby Conservation Area”.
It said that, although the site was just outside the town centre “I consider that a small scale cold food takeaway outlet in this location would not undermine the town centre of Tenby or its retail function and would not have any impact on its future viability and vitality,” adding: “To the contrary, the development would complement the role of the town centre by contributing to having a mix of uses within this edge of centre location, which is encouraged within Future Wales.”
On objections raised about a potential conflict between customers and other harbour users it said: “Whilst there would be instances of queuing outside the premises at busier times I am not persuaded that this would cause conflict with other users of the harbour or cause any hazard with harbour vehicles; the Highways Authority raised no objections to the scheme.”
On potential impacts on the Conservation Area and Tenby Castle, the Inspector noted concerns raised but said it “would not result in any visual impact on the historic harbour area or be unsympathetically sited within this historic landscape”.
The report also said, in terms of waste generation “the addition of another small premises would not have a detrimental impact on refuse levels in the area”.
After considering all the issues, the Inspector’s final conclusion stated: “Having regard to the above and considered all other matters raised by interested parties, I conclude that the appeal should be allowed.
“Planning permission for the takeaway cold food outlet at the former RNLI lifeboat store has therefore been granted.”
Business
Pembrokeshire holiday lets by pub to homes plans lodged
A CALL to convert holiday lets in a Pembrokeshire village to a single home for their owner to downsize has been submitted to county planners.
In an application to Pembrokeshire County Council, Dr Susan Richards, through agent Carl Bentley Architectural Services, seeks permission for a change of use and alteration works from two holiday let units to form one dwelling at Dovecote Cottage, Cosheston, near Pembroke Dock.
A supporting statement accompanying the application says: “This planning application seeks a change of use of the holiday let units known as Dovecote Cottage to form a new dwelling for the applicant to use as her main/only residence.
“The original farm/agricultural buildings at East Farm were converted from old farm outbuildings to self-catering holiday let units in the 1980s and 2010s partly by the previous owner and also partly by the current owner/applicant.”
It says Dr Richards, living at the village’s Little Mayeston Cottage, has been in the village since 2016, and has owned Dovecote Cottage, near the village’s Brewery Inn, since 2017, adding: “The applicant wishes to downsize from the current dwelling and relocate to a central village location to a smaller dwelling and be closer to friends within the village.”
Of the proposals it further says: “The holiday let units are semi-detached single storey traditional farm outbuildings of stone wall construction set under a pitched roof.
“One unit (known as Dovecote Cottage) provides two bedrooms of accommodation for four people, and the other unit (known as The Stable at Dovecote Cottage) provides one bedroom of accommodation for four people. Both units have open plan kitchens / dining and living areas plus separate shower rooms.”
The application will be considered by county planners at a later date.
-
Business2 days agoA proper Pembroke local: Inside the warm welcome of The Old Cross Saws Inn
-
Community7 days agoPolice intervene after post raises fears of planned Pembroke Dock fight
-
Crime7 days agoMan arrested after alleged child sexual assault in Haverfordwest
-
News7 days agoParty leaders on the spot in BBC programme live from Pembrokeshire College
-
Crime4 days agoOver 500 arrests at latest Palestine Action protest in London
-
Sport3 days agoGrand Slam win for Pembrokeshire rugby ace
-
Charity7 days agoDrive care forward: Help keep end-of-life care moving in Pembrokeshire
-
News7 days agoBBC brings election debate to Pembrokeshire College








